Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. II. Functional alterations of renal cortical mitochondria isolated after mercuric chloride treatment.
نویسندگان
چکیده
منابع مشابه
Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. I. Direct effects of in vitro mercuric chloride on renal mitochondrial function.
Increasing data suggest that mitochondrial dysfunction may be an important early component of nephrotoxin-induced changes in renal cell function and viability. This study was designed to obtain more detailed information about the effects on several basic bioenergetic parameters of the direct interaction of Hg2+ with renal cortical mitochondria in vitro as a necessary prelude to studies of mitoc...
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Background and Aims: Mercury, with its oxidative activity, causes damage to the antioxidant enzymes thus resulting in physiological disorders. Sodium selenide is an antioxidant that protects antioxidant enzymes. The aim of this study was to investigate the protective effect of sodium selenide on renal toxicity induced by mercuric chloride in rats. Materials and Methods: Animals were divided in...
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With the advent of modern ophthalmic treatment the use of mercury preparations in ophthalmology has almost been relegated to past history, but mercurous chloride (calomel) is still occasionally used as an insufflation into the eyes, especially in such conditions as phlyctenular keratoconjunctivitis. Recently we saw a case wherein mercuric chloride (HgCl2) was mistaken for calomel and dusted int...
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To help better understand the role of changes in cellular cation homeostasis in the pathogenesis of renal tubular cell injury, the alterations in cation content of renal cortex and isolated renal cortical mitochondria occurring during models of nephrotoxicity secondary to gentamicin and HgCl2 were determined both during a developing phase of injury prior to the appearance of cell necrosis and a...
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In the present investigation live specimens of Channa punctatus were collected, after acclimatization they were chronically exposed to sublethal concentrations of mercuric chloride for 15 and 30 days. As compared to the control fish, Mercury treated fish kidney showed marked histopathological changes. After 15 days the alterations detected initially were the widening of space between the capsul...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1982
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)68326-2